At CD BioGlyco, we provide Superior Analytical Services for a wide range of pharmaceuticals and biologicals. We provide β-cyclodextrin analysis services and propose an efficient, safe, and stable solution for the Pharmaceutical Excipient Analysis, which helps promote the sustainable development and innovation of the pharmaceutical industry.
β-cyclodextrin, used as a pharmaceutical excipient, primarily enhances drug stability, prevents oxidation and decomposition, boosts solubility and bioavailability, and reduces toxicity and side effects. Similarly, it can effectively mask drug odor, thus optimizing medication experience. With distinctive physiological and biochemical properties, β-cyclodextrin becomes uniquely advantageous in the pharmaceutical field. It efficiently safeguards active ingredients due to its high selectivity and chemical stability, thus improving drug efficacy and safety. Additionally, its edibility and ease of separation simplify its management in the pharmaceutical process.
We use advanced technology to accurately analyze the physicochemical properties of β-cyclodextrin. This includes the determination of key parameters such as molecular weight, solubility, hygroscopicity, melting point, and specific rotation. Through these analyses, we have a comprehensive understanding of the basic properties of β-cyclodextrin and provide strong support for drug development and production.
The purity and potential trace impurities of β-cyclodextrin are accurately determined using advanced analytical technologies such as high-performance liquid chromatography (HPLC) and gas chromatography (GC). These analytical data are crucial to ensuring the quality and safety of pharmaceutical excipients, and help clients control risks during drug development and production.
We use modern analytical methods such as infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) to identify and characterize the structure of β-cyclodextrin. These analyses reveal key information such as the molecular structure and functional group distribution of β-cyclodextrin and provide clients with a strong basis for an in-depth understanding of the physiological and biochemical properties of β-cyclodextrin.
As a pharmaceutical excipient, the functionality of β-cyclodextrin is the key to its application. We conduct specialized analysis on the inclusion performance, solubilization effect, stability, etc. of β-cyclodextrin. By simulating the actual drug preparation process, we evaluate the performance of β-cyclodextrin under different conditions and provide the scientific basis for clients to select appropriate pharmaceutical excipients.
In addition to the regular analysis services mentioned above, we also provide customized analysis services. According to the specific needs of clients and the different stages of drug development, we develop personalized analysis plans and provide targeted technical support and solutions.
Technology: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis
Journal: Molecules
IF: 4.6
Published: 2022
Results: The researchers innovatively constructed a technical method based on LC-MS/MS to efficiently and accurately simultaneously measure the content of the drug carrier β-cyclodextrin and the active pharmaceutical ingredient dextromethorphan hydrobromide. Besides, they used this advanced technology to conduct an in-depth study of the pharmacokinetic characteristics, tissue distribution patterns, excretion pathways, and metabolic processes of β-cyclodextrin in rats. Research results showed that β-cyclodextrin is almost completely cleared from rat plasma within 36 hours after administration, and it can be rapidly distributed to organs with rich blood flow after administration. However, intact β-cyclodextrin is not excreted in urine and feces at the administered dose.
Fig.1 Full-scan product ion spectrums of β-cyclodextrin (a) (m/z 1135.6/325.2), dextromethorphan hydrobromide (DM) (b) (m/z 272.0/171.0), ginsenoside Re (c) (m/z 989.6/789.6), and Psoralen (d) (m/z 187.1/131.1). (Mu, et al., 2022)
Its unique molecular structure and functions have made it a popular choice in the pharmaceutical excipient industry. This compound, represented by the formula C42H70O35 and a molecular weight of 1134.98, is usually found as a white or light yellow powder. It also possesses a distinctive pectin-like aroma and a taste that is mildly sweet and sour. While soluble in water, β-cyclodextrin doesn't dissolve in ethanol or other organic solvents.
The purity of β-cyclodextrin is critical to drug quality. High-purity β-cyclodextrin ensures the stability and effectiveness of pharmaceutical preparations and reduces potential risks caused by impurities. Through our purity and impurity analysis services, we accurately determine the purity of β-cyclodextrin and strictly monitor trace impurities in it to ensure that the quality of pharmaceutical excipients meets relevant requirements.
CD BioGlyco has a professional technical team to provide clients with comprehensive and accurate β-cyclodextrin analysis services. We always pay attention to the needs of our clients and are committed to promoting progress and development in the field of drug research and development. Please feel free to contact us if you are interested in our β-cyclodextrin analysis service.
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