Polysaccharide-based Biodegradable Wound Repair and Tissue Reconstruction Material

Polysaccharide-based Biodegradable Materials for Wound Repair and Tissue Reconstruction

Wound repair refers to a series of pathological and physiological processes in which local tissues are repaired and restored through regeneration and reconstruction after skin or other tissues have been severed or damaged due to trauma or other reasons. The process of wound repair is divided into three stages: hemostasis and inflammation, cell proliferation and differentiation, and tissue reconstruction or scar formation. Polysaccharide-based materials are expected to be ideal for wound repair due to their biocompatibility and biodegradability to treat or replace defective tissues in the body and promote wound healing and repair.

In contrast to conventional wound dressings, polysaccharide-based hydrogel wound dressings can mimic extracellular matrix functions to promote cell adhesion, growth, and proliferation to accelerate the healing process. These materials are promising supporters for wound healing applications. In addition, polysaccharide-based hydrogels have specific physicochemical properties and unique therapeutic interventions due to their rich functional groups and unique structures, opening up new avenues for wound healing and tissue reconstruction.

Fig.1 Oxidized plant-polysaccharides-chitosan hydrogel (OPH) samples blood coagulation performance, cell compatibility, and cytotoxicity. (Xue, et al., 2022)

Development Services for Polysaccharide-based Biodegradable Wound Repair and Tissue Reconstruction Materials at CD BioGlyco

Our researchers work on the development of many types of polysaccharide-based dressings or the modification of polysaccharide-based hydrogels to provide more precise control of the gel's physicochemical properties including mechanical, rheological, and swelling characteristics. We help our clients synthesize polysaccharide-based hydrogels adapted to various types of wounds, such as burn wounds, chronic diabetic wounds, and acute wounds.

• Preparation of polysaccharide hydrogels
  We help our clients to prepare polysaccharide-based hydrogels with two techniques.
  
  • Physical crosslinking methods
    We create physically crosslinked 3D networks by techniques such as freeze-thawing, pH reduction, selection of anionic and cationic polymers, and heating or cooling of polymer solutions. These methods rely on physical interactions such as hydrogen bonding, crystallization, ionic interactions, chain entanglement, and hydrophobic interactions.
  • Chemical crosslinking methods
    We help our clients prepare polysaccharide-based hydrogels through enzyme-mediated crosslinking, chemical reactions of complementary groups, and radiation techniques. We use chemical crosslinking agents to improve the morphological and biomechanical properties of polysaccharide-based hydrogels.
    We offer our clients a wide range of polysaccharide-based hydrogels, including but not limited to:
    
    • Chitosan-based hydrogels
    • Alginate-based hydrogels
    • Hyaluronic acid-based hydrogels
    • Cellulose-based hydrogels
    • Dextran-based hydrogels

    • Starch-based hydrogels
    • Tragacanth gum-based hydrogels
    • Pectin-based hydrogels
    • Carrageenan-based hydrogels
• Design of polysaccharide-based hydrogels loaded with several therapeutic agents
  Our researchers work to help clients design polysaccharide-based hydrogels loaded with multiple therapeutic agents, such as growth factors. These hydrogels combine the dual benefits of healing from polysaccharides and therapeutic agents, ultimately leading to rapid wound healing.
  
  • Delivery of growth factors, such as epidermal growth factor.
  • Delivery of essential oils, such as ginger essential oil (GEO).
  • Delivery of antimicrobial agents, such as ciprofloxacin, naproxen, and amikacin.
  • Delivery of bioactive agents, such as polyphenols with diverse characteristics.
  • Delivery of stem cells.

Over the years, CD BioGlyco has gained extensive experience in Carbohydrate-based Degradable Materials Development and has helped our clients achieve success in several projects. We are continuously working on the development of smart polysaccharide-based hydrogels to advance precision and personalized medicine.

If you are interested in our development services for polysaccharide-based biodegradable wound repair and tissue reconstruction materials, please feel free to contact us for more details.