Blood Group and Lewis Antigen
Blood groups are defined by oligosaccharide structures that are specific to antigens. The ABO blood group system is associated with A, B, and H antigens, whose specificity lies in the differences in the terminal carbohydrate residues. The H antigen is synthesized by adding fucosyl residues to a precursor oligosaccharide. The addition of N-acetylgalactosamine residues to the H antigen produces the A antigen, while the addition of galactose residues produces the B antigen. Small changes in the oligosaccharide structure not only affect the classification of blood groups but also have an impact on immune responses, biorecognition, and pathogen-host interactions. CD BioGlyco is a specialist glycobiology company that has invested heavily in the development of blood group and Lewis antigen products to promote and accelerate scientific research in related fields.
Fig.1 The major characteristics of the ABO blood group system. (Pendu, et al., 2021)
ABO tissue blood group antigens are expressed on red blood cells and widely distributed in various tissues. Blood group antigens are further divided into six subtypes based on linkage arrangement.
Table 1 The six subtype structures of blood group antigens. (CD BioGlyco)
| Subtypes | Structures |
| Blood group antigen type I | ABO-β(1,3)GlcNAc |
| Blood group antigen type II | ABO-β(1,4)GlcNAc |
| Blood group antigen type III | ABO-β(1,4)GalNAc |
| Blood group antigen type IV | ABO-β(1,3)GalNAc |
| Blood group antigen type V | ABO-β(1,3)Gal |
| Blood group antigen type VI | ABO-β(1,4)Glc |
We provide clients with ABH blood group antigen products of different subtypes, such as blood group A tetrasaccharide type V, blood group B type I linear trisaccharide, and blood group H tetraose type II. We also couple Sepharose, bovine serum albumin (BSA), and human serum albumin (HSA) with blood group antigens to develop conjugates. Lewisa and Lewisb are the two main antigens in the Lewis tissue blood group system. We provide clients with high-quality Lewis A, Lewis B, Lewis X, and Lewis Y products to support your innovative research.
Blood group A products are developed specifically to advance the science of blood type A research and are core tools for studying blood type A-specific antigen expression and its role in immune response. By utilizing these highly pure and specific sugar molecules, researchers have deeply analyzed the biochemical properties and molecular mechanisms of blood type A and explored its potential for application in transfusion medicine, immunology, and blood type-related genetic diseases. Partial products are listed here, find more blood group A antigen products in the drop-down list.
We have expertise in developing blood group B products, offering our clients a range of products from standard blood group B oligosaccharides to functionalized blood group B antigen products. These products are essential tools for studying blood group compatibility issues, diseases associated with blood group B, and developing novel therapeutic approaches involving blood group B antigens. Please find more blood group B antigen products in the drop-down list.
The basic structure of H antigen not only defines the characteristics of blood type O but is also an indispensable precursor in the formation of blood types A and B. The blood group H antigen products we provide include blood group disaccharides, trisaccharides, tetrasaccharides, pentasaccharides, and functionalized blood group H antigens, which play an important role in biochemical property research and immune recognition. Please find more blood group B antigen products in the drop-down list.
Our Lewis antigen products include highly purified Lewis A, Lewis B, Lewis X, and Lewis Y, which researchers rely on to study the role of Lewis antigens in cancer, infection, and other diseases, as well as to explore their potential use in personalized medicine and therapeutic development. Please find more blood group B antigen products in the drop-down list.
DOI: 10.3390/biology6010016
Journal: Biology
IF: 3.6
Published: 2017
Results: The authors summarize the biosynthesis of sLex and sLea in cell lines and native tissues of gastrointestinal origin, understanding the relationship between their expression and various cancer phenotypes. The authors also discuss the use of such molecules in gastrointestinal cancer diagnostics, especially the possible use in the early detection of pancreatic cancer. Finally, the authors review data on the mechanism of the link between selectin ligand expression in gastrointestinal cells and cancer malignancy.
Fig.2 Structure and biosynthesis of Lewis antigens. (Trinchera, et al., 2017)
At CD BioGlyco, our blood group and Lewis antigen products demonstrate excellent performance and reliability in disease research, immune research, and genetic analysis. Whether used for basic research or developing innovative diagnostic testing methods, our products provide strong support for scientists. Please feel free to contact us.
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