BMY 7378

Synonym: 21102-95-4; 8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

CAS Number: 21102-95-4
Compound CID: 210172

Product Size

10 mg; 50 mg; 200 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BMY 7378, soluble in DMSO, ethanol and water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets α1D-adrenoceptor, DopamineD2 receptor, α2-adrenoceptor, α2C-adrenoceptor, β1-adrenoceptor, β2-adrenoceptor, 5-HT1A, 5-HT1C, 5-HT1D, 5-HT2, and 5-HT3.

Molecular Weight

458.42

Molecular Formula

C₂₂H₃₁N₃O₃·2HCl

Targets

α1D-adrenoceptor: 8.2 (pki); Dopamine D2 receptor: 7.4 (pIC₅₀); α2-Adrenoceptor: 5.1 (pIC₅₀); α2C-adrenoceptor: 6.54 (pki); β1-Adrenoceptor: 5.1 (pIC₅₀); β2-Adrenoceptor: <5.0 (pIC₅₀); 5-HT1A: 8.3 (pIC₅₀); 5-HT1C: 6.4 (pIC₅₀); 5-HT1D: 5.9 (pIC₅₀); 5-HT2: 5.5 (pIC₅₀); 5-HT3: <5.0 (pIC₅₀)

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 81 mg/mL (176.69 mM); Water: 81 mg/mL (176.69 mM); Ethanol: 18 mg/mL (39.26 mM)

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

BMY 7378 can be used to modulate serotonin signaling pathways, potentially influencing conditions associated with serotonin dysfunction.

Storage

Store at -20°C, and keep desiccated.