Properties
Description
Bosentan inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets ET-A, and ET-B.
Molecular Formula
C27H29N5O6S
Targets
ET-A: 4.7 nM (Ki); ET-B: 95 nM (Ki)
Applications
Bosentan can be used to helps improve exercise capacity and delay disease progression in patients with PAH.
