Properties
Description
BRL-54443, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT1F receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT6 receptor, and 5-HT7 receptor.
Molecular Formula
C14H18N2O
Targets
5-HT1A receptor: 63 nM; 5-HT1B receptor: 126 nM; 5-HT1D receptor: 63 nM; 5-HT1E receptor: 1.1 nM; 5-HT1F receptor: 0.7 nM; 5-HT2A receptor: 1259 nM; 5-HT2B receptor: 100 nM; 5-HT2C receptor: 316 nM; 5-HT6 receptor: >10,000 nM; 5-HT7 receptor: >10,000 nM
Solubility
DMSO: 40 mg/mL (173.68 mM); Water: insoluble; Ethanol: 2 mg/mL (8.68 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BRL-54443 can be used for its ability to modulate the endocannabinoid system to influence these processes.
Storage
Store at -20°C, and keep desiccated.
