Properties
Description
ACP-196, soluble in DMSO and ethanol and insoluble in water, is a compound designed to block Bruton’s tyrosine kinase (BTK), an enzyme essential for the proliferation and survival of certain cancerous B cells. It targets BTK.
Molecular Formula
C26H23N7O2
Solubility
DMSO: 80 mg/mL (171.85 mM); Water: Insoluble; Ethanol: 80 mg/mL (171.85 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
ACP-196 (Acalabrutinib) is used to study B-cell receptor pathway disruption in the treatment of chronic lymphocytic leukemia (CLL) and other B-cell malignancies.
