BTK inhibitor AVL-292, Purity ≥98%

Synonym: 1202757-89-8; BTK inhibitor; AVL292; AVL 292; CC292; CC-292; CC 292

MDL: MFCD25976876
CAS Number: 1202757-89-8
Compound CID: 59174488

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AVL-292, soluble in DMSO and insoluble in ethanol and water, is a compound designed to block Bruton’s tyrosine kinase (BTK), an enzyme essential for the proliferation and survival of certain cancerous B cells. It targets c-Src, YES, BRK, BTK, CSK, Fyn, Hck, LCK, and Lyn.

Molecular Weight

423.44

Molecular Formula

C₂₂H₂₂FN₅O₃

Targets

c-Src: 1.729 μM; YES: 723 μM; BRK: 2.43 μM; BTK: <0.5 nM; CSK: <0.5 nM; Fyn: 7.146 μM; Hck: 14.46 μM; LCK: 9.079 μM; Lyn: 4.401 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 78 mg/mL (184.2 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AVL-292 is applied to study the inhibition of Bruton’s tyrosine kinase in B-cell-mediated diseases, contributing to drug development for conditions like leukemia and lymphoma.