BTK inhibitor PCI-32765, Purity ≥98%

Synonym: 936563-96-1; BTK inhibitor; Ibrutinib

MDL: MFCD20261150
CAS Number: 936563-96-1
Compound CID: 24821094

Product Size

10 mg; 25 mg; 100 mg; 200 mg

Price

Datasheet

MSDS

Properties

Description

PCI-32765, soluble in DMSO and ethanol and insoluble in water, is a compound designed to block Bruton’s tyrosine kinase (BTK), an enzyme essential for the proliferation and survival of certain cancerous B cells. It targets BLK, BMX, Abl, BRK, BTK, c-Src, CSK, EGFR, ErbB2, FER, and FGR.

Molecular Weight

440.5

Molecular Formula

C₂₅H₂₄N₆O₂

Targets

BLK: 0.5 nM; BMX: 0.8 nM; Abl: 86 nM; BRK: 3.3 nM; BTK: 0.5 nM; c-Src: 171 nM; CSK: 2.3 nM; EGFR: 5.6 nM; ErbB2: 9.4 nM; FER: 8.07 nM; FGR: 2.3 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 81 mg/mL (183.88 mM); Water: Insoluble; Ethanol: 41 mg/mL (93.07 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

PCI-32765 also known as Ibrutinib, is a BTK inhibitor with applications in cancer research.