c-MET inhibitor AMG-458, Purity ≥98%

Synonym: 913376-83-7; c-MET inhibitor; AMG458; AMG 458

CAS Number: 913376-83-7
Compound CID: 24764449

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AMG-458, soluble in DMSO and insoluble in ethanol and water, inhibits the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), interfering with pathways leading to cell growth and metastasis. It targets c-Met (human), c-Met (V1092I), c-Met(D1228H), c-Met(H1094R), c-Met(M1250T), c-Met(Mouse), c-Met(Y1230H), and VEGFR2.

Molecular Weight

539.6

Molecular Formula

C₃₀H₂₉N₅O₅

Targets

c-Met (human): 1.2 nM (Ki); c-Met (V1092I): 1.1 nM (Ki); c-Met (D1228H): 2.2 nM (Ki); c-Met (H1094R): 0.5 nM (Ki); c-Met (M1250T): 4.1 nM (Ki); c-Met (mouse): 2.0 nM (Ki); c-Met (Y1230H): 4.5 nM (Ki); VEGFR2: 4.1 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 18 mg/mL (33.35 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AMG-458 is used to explore the inhibition of c-MET, which plays a significant role in cancer cell growth and metastasis.