Properties
Description
NPS-1034, soluble in warmed DMSO and ethanol and insoluble in water, inhibits the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), interfering with pathways leading to cell growth and metastasis. It targets Axl and Met.
Molecular Formula
C31H23F2N5O3
Targets
Axl: 10.3 nM; Met: 48 nM
Solubility
Warmed DMSO: 95 mg/mL (172.24 mM); Water: Insoluble; Ethanol: 4 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
NPS-1034 is used to inhibit c-MET, providing insights into therapeutic strategies against cancer.
