Properties
Description
AD80, soluble in DMSO and ethanol and insoluble in water, primarily acts by blocking the ATP-binding site of the kinase domain of the RET protein, thereby inhibiting its autophosphorylation. It targets RAF, RET, and SRC.
Molecular Formula
C22H19F4N7O
Solubility
DMSO: 91 mg/mL (192.21 mM); Water: Insoluble; Ethanol: 91 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AD80 is used to study its multi-kinase inhibitory effects, particularly in cancer cell growth and survival.
