c-Ret inhibitor Amuvatinib hydrochloride, Purity ≥98%

Synonym: 1055986-67-8; c-Ret inhibitor; MP470 hydrochloride; MP 470; MP-470; HPK 56 hydrochloride; HPK56; HPK-56

CAS Number: 1055986-67-8
Compound CID: 16058702

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Amuvatinib hydrochloride primarily acts by blocking the ATP-binding site of the kinase domain of the RET protein, thereby inhibiting its autophosphorylation. It targets c-Kit (D816H), c-Kit (D816V), c-Kit (V560G), c-Kit (V654A), PDGFRα (D842V), and PDGFRα (V561D).

Molecular Weight

483.97

Molecular Formula

C₂₃H₂₁N₅O₃S.xHCl

Targets

c-Kit (D816H): 10 nM; c-Kit (D816V): 950 nM; c-Kit (V560G): 34 nM; c-Kit (V654A): 127 nM; PDGFRα (D842V): 81 nM; PDGFRα (V561D): 40 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

Amuvatinib hydrochloride serves as a c-Ret inhibitor used in researching targeted cancer therapies, particularly for tumors with c-Ret mutations.