CD BioGlyco offers a range of Pharmaceutical and Biological Analysis Services, including Pharmaceutical Analysis Service, Biological Evaluation Service, and Pharmaceutical Excipient Analysis Services. We provide tests and analysis for various pharmaceutical ingredients, such as calcium saccharate. Calcium saccharate, derived from D-glucose, is the calcium salt form of glucaric acid found in fruits and vegetables. With its ability to inhibit beta-glucuronidase activity, it shows promise as an anticancer agent. By supplementing it, one can regulate estrogen metabolism and lower lipid levels thereby enhancing enterohepatic circulation and reducing cholesterol synthesis. It's worth mentioning that calcium saccharate is utilized as an excipient, stabilizer, and acidifier.
The light produces optical rotation, which results in a plane of polarization that shifts between the two directions and we call this optical rotation. We utilize a polarimeter to analyze the specific optical rotation of the sample. This measurement is intended to help identify or assess the purity of optically active substances and determine their contents. We conduct optical rotation measurements within 30 minutes of preparing the solution. The measuring tube is washed several times with the test solution to measure optical rotation, and then the test solution is slowly injected into the tube to prevent the formation of bubbles. In order to obtain the optical rotation of the test solution, place the tube in the polarimeter for reading.
We carry out rigorous identification of the samples to enable the accuracy and reliability of results. Two methods of identification will be used for the identification of the calcium saccharate sample, thereby reducing the risk of misinterpretation.
We have the expertise to carry out comprehensive content analyses using a range of methodologies, making sure our findings are as precise and reliable as possible.
We will dissolve the sample in the mixture of dilute nitric acid and water, and compare it with the control solution prepared from standardized sodium solution and standardized potassium sulfate solution, respectively.
We test to measure the levels of heavy metals, like lead, cadmium, and mercury in the sample.
To prevent the spread of pathogens that may pose a health threat, we will investigate the existence of microorganisms, like bacteria, yeast, E. Coli, and mold.
Technology: Computer simulation
Journal: Nutrients
IF: 5.9
Published: 2023
Results: In this study, authors used computer simulations to analyze the positive effect of the supplementation of calcium saccharate and their metabolite D-glucaric acid on mitigation of liver detoxification. The authors used CytoSolve to integrate these molecular mechanisms, constructing a computational framework for conducting in-silico experiments. This framework quantified the impact of GA on specific biomarkers of liver toxicity through four primary mechanisms. It was shown that D-glucaric acid enhances liver detoxification by decreasing hepatocyte apoptosis, lowering glucuronide deconjugate levels, reducing ROS production, and inhibiting the β-glucuronidase enzyme, thereby preventing toxin reabsorption in hepatocytes.
CD BioGlyco possesses various advanced methodologies to support our clients develop and research innovative pharmaceutical formulations. Based on different applications, a series of unique analysis schemes will be made by our research team. Our research team has the expertise in dealing with complex drug development issues. Contact us if you need to know whether excipients are compatible with the medicinal product or check their stability in formulations that have been modified according to different conditions.
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