Properties
Description
Belnacasan, soluble in warmed DMSO and warmed ethanol and insoluble in water, inhibits the activity of caspases, thereby preventing apoptosis. It targets Caspase-4 and Caspase-1.
Molecular Formula
C24H33ClN4O6
Targets
Caspase-4: <0.6 nM (Ki); Caspase-1: 0.8 nM (Ki)
Solubility
Warmed DMSO: 87 mg/mL (170.92 mM); Water: Insoluble; Warmed ethanol: 87 mg/mL (170.92 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Belnacasan (VX-765) can be used to research the inhibition of interleukin-1尾 converting enzyme (caspase-1) and its effects on inflammatory diseases.