Caspase inhibitor Belnacasan, Purity ≥98%

Synonym: 273404-37-8; BELNACASAN; VX-765; Belnacasan (VX-765); VX765; Belnacasan [USAN]; (S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide; Caspase inhibitor

MDL: MFCD11100350
CAS Number: 273404-37-8
Compound CID: 11398092

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Belnacasan, soluble in warmed DMSO and warmed ethanol and insoluble in water, inhibits the activity of caspases, thereby preventing apoptosis. It targets Caspase-4 and Caspase-1.

Molecular Weight

509

Molecular Formula

C₂₄H₃₃ClN₄O₆

Targets

Caspase-4: <0.6 nM (Ki); Caspase-1: 0.8 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 87 mg/mL (170.92 mM); Water: Insoluble; Warmed ethanol: 87 mg/mL (170.92 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Belnacasan (VX-765) can be used to research the inhibition of interleukin-1尾 converting enzyme (caspase-1) and its effects on inflammatory diseases.

Storage

Store at -20ºC.