Properties
Description
Cenicriviroc, soluble in DMSO and ethanol and insoluble in water, specifically binds to chemokine receptors. This binding blocks the receptors and prevents the corresponding chemokines from exerting their effects on immune cells, leading to reduced chemotaxis and cell activation.
Molecular Formula
C41H52N4O4S
Solubility
DMSO: 94 mg/mL (134.87 mM); Water: Insoluble; Ethanol: 94 mg/mL (134.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Cenicriviroc can be leveraged to explore its dual antagonist activity on CCR2 and CCR5 in models of nonalcoholic steatohepatitis (NASH) and fibrosis.
