Properties
Description
5-Iodo-indirubin-3'-monoxime is an CDK kinase inhibitor that disrupts cell division processes. It targets Cdk1/cyclin B, Cdk5/p25, and GSK-3β.
Molecular Formula
C16H10IN3O2
Targets
Cdk1/cyclin B: 25 nM; Cdk5/p25: 20 nM; GSK-3β: 9 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
5-Iodo-indirubin-3'-monoxime can be used to explore its kinase inhibitory effects, including CDKs, in the context of cancer treatment.