Properties
Description
AT7519 HCl, soluble in warmed DMSO, warmed water and warmed ethanol, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK2/CyclinA, CDK5/p35, AuroraA, and c-Abl.
Molecular Formula
C16H17Cl2N5O2.HCl
Targets
CDK2/CyclinA: 47 nM; CDK5/p35: 13 nM; AuroraA: >10 μM; c-Abl: >10 μM
Solubility
Warmed DMSO: 49 mg/mL (117.03 mM); Warmed water: 40 mg/mL (95.53 mM); Warmed ethanol: 26 mg/mL (62.09 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AT7519 HCl is used to study its inhibitory activity against multiple CDKs and its effects in cancer therapy.
