Properties
Description
AT7519, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK2/CyclinA, CDK5/p35, AuroraA, and c-Abl.
Molecular Formula
C16H17Cl2N5O2
Targets
CDK2/CyclinA: 47 nM; CDK5/p35: 13 nM; AuroraA: >10 μM; c-Abl: >10 μM
Solubility
DMSO: 9 mg/mL (23.54 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AT7519 can be used to study its role as a cyclin-dependent kinase (CDK) inhibitor and its effects on inducing apoptosis in cancer cells.
