Properties
Description
AZD5438, soluble in DMSO and ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1-cyclin B1, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1.
Molecular Formula
C18H21N5O2S
Targets
CDK1-cyclin B1: 16 nM; cdk2-cyclin A: 45 nM; cdk2-cyclin E: 6 nM; cdk4-cyclin D1: 449 nM
Solubility
DMSO: 68 mg/mL (183.06 mM); Water: Insoluble; Ethanol: 68 mg/mL (183.06 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZD5438 is employed to investigate its inhibition of multiple CDKs and its implications for cancer therapy.
