Properties
Description
BI 2536, soluble in DMSO and ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets PLK2, PLK3, βIRK, and Abl.
Molecular Formula
C28H39N7O3
Targets
PLK2: 3.5 nM; PLK3: 9.0 nM; βIRK: >10 μM; Abl: >10 μM
Solubility
DMSO: 21 mg/mL (40.25 mM); Water: Insoluble; Ethanol: 98 mg/mL (187.86 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BI 2536 can be used to study its effects as a Plk1 inhibitor in cell cycle regulation and cancer therapy.
