Properties
Description
Bohemine, soluble in DMSO and ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK2/cyclin A, CDK2/cyclinE, CDK9/cyclinT1, and ERK2.
Molecular Formula
C18H24N6O
Targets
CDK2/cyclin A: 83 μM; CDK2/cyclinE: 4.6 μM; CDK9/cyclinT1: 2.7 μM; ERK2: 52 μM
Solubility
DMSO: 61 mg/mL (179.19 mM); Water: Insoluble; Ethanol: 61 mg/mL (179.19 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Bohemine can be used to investigate cell cycle regulation by inhibiting cyclin-dependent kinases (CDKs).
