Properties
Description
BS-181 hydrochloride, soluble in DMSO, water and warmed ethanol, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1/cycB, CDK2/Cyc E, CDK4/Cyc D1, and CDK5/p35NCK.
Molecular Formula
C22H33ClN6
Targets
CDK1/cycB: 8.1 μM; CDK2/Cyc E: 0.88 μM; CDK4/Cyc D1: 33 μM; CDK5/p35NCK: 3 μM
Solubility
DMSO: 81 mg/mL (194.24 mM); Water: 3 mg/mL (7.19 mM); Warmed ethanol: 22 mg/mL (52.75 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BS-181 hydrochloride is used to research its selective inhibition of CDK7 and its effects on cell cycle progression.
