Properties
Description
CCT245737, soluble in warmed DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets AMPK, BRSK1, CDK1/CyclB, and CDK2/CyclA.
Molecular Weight
379.3472
Molecular Formula
C16H16F3N7O
Targets
AMPK: 2970 nM; BRSK1: 1660 nM; CDK1/CyclB: 9030 nM; CDK2/CyclA: 3850 nM
Solubility
Warmed DMSO: 72 mg/mL (189.8 mM); Water: Insoluble; Warmed ethanol: 9 mg/mL (23.72 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CCT245737 can be used to explore its activity as a CHK1 inhibitor and its role in sensitizing cancer cells to chemotherapy.
