CDK inhibitor CCT245737, Purity ≥98%

Synonym: 1489389-18-5; CCT 245737; CCT-245737; CDK inhibitor

CAS Number: 1489389-18-5
Compound CID: 72165232

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CCT245737, soluble in warmed DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets AMPK, BRSK1, CDK1/CyclB, and CDK2/CyclA.

Molecular Weight

379.3472

Molecular Formula

C₁₆H₁₆F₃N₇O

Targets

AMPK: 2970 nM; BRSK1: 1660 nM; CDK1/CyclB: 9030 nM; CDK2/CyclA: 3850 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 72 mg/mL (189.8 mM); Water: Insoluble; Warmed ethanol: 9 mg/mL (23.72 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

CCT245737 can be used to explore its activity as a CHK1 inhibitor and its role in sensitizing cancer cells to chemotherapy.