CDK inhibitor JNJ-7706621, Purity ≥98%

Synonym: JNJ-7706621; 443797-96-4; JNJ7706621; 4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide; 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide; 4-({5-Amino-1-[(2,6-Difluorophenyl)carbonyl]-1H-1,2,4-Triazol-3-Yl}amino)benzenesulfonamide; CDK inhibitor

CAS Number: 443797-96-4
Compound CID: 5330790

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

JNJ-7706621, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets Aurora A, Aurora B, Cdk1/cyclin B, cdk2/cyclin A, CDK2/cyclinE, CDK3/cyclinE, Cdk4/cyclin D1, CDK6/cyclinD1, FGF-R1, FGF-R2, and GSK3β.

Molecular Weight

394.4

Molecular Formula

C₁₅H₁₂F₂N₆O₃S

Targets

Aurora A: 11 nM; Aurora B: 15 nM; Cdk1/cyclin B: 9 nM; cdk2/cyclin A: 4 nM; CDK2/cyclinE: 3 nM; CDK3/cyclinE: 58 nM; Cdk4/cyclin D1: 253 nM; CDK6/cyclinD1: 175 nM; FGF-R1: 575 nM; FGF-R2: 226 nM; GSK3β: 254 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 67 mg/mL (169.89 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

JNJ-7706621 is useful for studying the inhibition of multiple cell cycle kinases including Aurora kinase.

Storage

Store at -20ºC.