Properties
Description
K03861, soluble in DMSO and ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK2(A144C), CDK2(C118L), CDK2(C118L/A144C), and CDK2(WT).
Molecular Formula
C24H26F3N7O2
Targets
CDK2(A144C): 15.4 nM (Kd); CDK2(C118L): 18.6 nM (Kd); CDK2(C118L/A144C): 9.7 nM (Kd); CDK2(WT): 50 nM(Kd)
Solubility
DMSO: 97 mg/mL (193.42 mM); Water: Insoluble; Ethanol: 15 mg/mL (29.91 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
K03861 can be used to study the inhibition of CDKs and its potential therapeutic applications in cancer research.
