Properties
Description
Lerociclib, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1/cyclinB1, cdk2/cyclin A, CDK2/cyclinE, and Cdk4/cyclin D1.
Molecular Formula
C26H34N8O
Targets
CDK1/cyclinB1: 2.4 μM; cdk2/cyclin A: 1.5 μM; CDK2/cyclinE: 3.6 μM; Cdk4/cyclin D1: 1 nM
Solubility
DMSO: 2 mg/mL (4.21 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Lerociclib can be used to investigate its selective inhibition of CDK4/6 and potential for treating advanced breast cancer.
