CDK inhibitor LY2835219, Purity ≥98%

Synonym: 1231929-97-7; LY 2835219; LY-2835219; Abemaciclib; CDK inhibitor

CAS Number: 1231929-97-7
Compound CID: 46220502

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY2835219, soluble in DMSO and ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1/cyclinB1, CDK2/cyclinE, Cdk4/cyclin D1, and Cdk5/p25.

Molecular Weight

506.59

Molecular Formula

C₂₇H₃₂F₂N₈

Targets

CDK1/cyclinB1: 1627 nM; CDK2/cyclinE: 504 nM; Cdk4/cyclin D1: 2 nM; Cdk5/p25: 355 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 6 mg/mL (11.84 mM); Water: Insoluble; Ethanol: 8 mg/mL (15.79 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

LY2835219 (Abemaciclib) can be used to study the targeted inhibition of CDK4/6 in cancer therapies.

Storage

Store at -20ºC.