Properties
Description
ML167, soluble in DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CLK1, CLK2, CLK4, and Dyrk1B.
Molecular Formula
C19H17N3O3
Targets
CLK1: 1522 nM; CLK2: 1648 nM; CLK4: 136 nM; Dyrk1B: 4420 nM
Solubility
DMSO: 64 mg/mL (190.83 mM); Water: Insoluble; Warmed ethanol: 12 mg/mL (35.78 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
ML167 can be used to study the inhibition of CDK7 and CDK9 and their roles in cellular processes.