CDK inhibitor NMS-1286937, Purity ≥98%

Synonym: 1034616-18-6; NMS1286937; NMS-P937; CDK inhibitor

CAS Number: 1034616-18-6
Compound CID: 49792852

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

NMS-1286937, soluble in warmed DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets PLK1, PLK2, and PLK3.

Molecular Weight

532.52

Molecular Formula

C₂₄H₂₇F₃N₈O₃

Targets

PLK1: 2 nM; PLK2: >10 μM; PLK3: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 38 mg/mL (71.36 mM); Water: Insoluble; Warmed ethanol: 9 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

NMS-1286937 is used to explore its inhibitory activity against CHK1 and its potential in enhancing the efficacy of DNA-damaging agents in cancer treatment.