Properties
Description
NMS-1286937, soluble in warmed DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets PLK1, PLK2, and PLK3.
Molecular Formula
C24H27F3N8O3
Targets
PLK1: 2 nM; PLK2: >10 μM; PLK3: >10 μM
Solubility
Warmed DMSO: 38 mg/mL (71.36 mM); Water: Insoluble; Warmed ethanol: 9 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
NMS-1286937 is used to explore its inhibitory activity against CHK1 and its potential in enhancing the efficacy of DNA-damaging agents in cancer treatment.
