CDK inhibitor ON123300, Purity ≥98%

Synonym: 1357470-29-1; ON123300; ON 123300; CDK inhibitor

CAS Number: 1357470-29-1
Compound CID: 56649281

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ON123300, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets ARK5, Cdk4/cyclin D1, CDK6/cyclinD1, and FGFR1.

Molecular Weight

429.23

Molecular Formula

C₂₄H₂₇N₇O

Targets

ARK5: 5 nM; Cdk4/cyclin D1: 3.9 nM; CDK6/cyclinD1: 9.82 nM; FGFR1: 26 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 26 mg/mL (60.53 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

ON123300 can be used to study the dual inhibition of CDK4/6 and ARK5 in cancer cells.

Storage

Store at -20ºC.