Properties
Description
P276-00, soluble in DMSO, water and ethanol, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1/CyclinB, CDK4/CyclinD1, c-Src, and CDK2/CyclinA.
Molecular Formula
C21H20ClNO5.HCl
Targets
CDK1/CyclinB: 79 nM; CDK4/CyclinD1: 63 nM; c-Src: <10 μM; CDK2/CyclinA: 224 nM
Solubility
DMSO: 79 mg/mL (180.24 mM); Water: 79 mg/mL (180.24 mM); Ethanol: 6 mg/mL (13.69 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
P276-00 can be used to study the inhibition of CDK9 and its effects on transcription.