Properties
Description
Palbociclib is an CDK kinase inhibitor that disrupts cell division processes. It targets Cdk4/cyclin D1, Cdk4/cyclin D3, Cdk6/cyclin D2, and DYRK1A.
Molecular Formula
C24H29N7O2
Targets
Cdk4/cyclin D1: 11 nM; Cdk4/cyclin D3: 9 nM; Cdk6/cyclin D2: 16 nM; DYRK1A: 2000 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Palbociclib (PD 0332991) can be used to study the selective inhibition of CDK4/6 in cancer therapy.