Properties
Description
Palbociclib is an CDK kinase inhibitor that disrupts cell division processes. It targets Cdk4/cyclin D1, Cdk4/cyclin D3, Cdk6/cyclin D2, and DYRK1A.
Molecular Formula
C24H29N7O2
Targets
Cdk4/cyclin D1: 11 nM; Cdk4/cyclin D3: 9 nM; Cdk6/cyclin D2: 16 nM; DYRK1A: 2000 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
Palbociclib (PD 0332991) can be used to study the selective inhibition of CDK4/6 in cancer therapy.