Properties
Description
PD 0332991 HCl, soluble in warmed DMSO and water and insoluble in ethanol, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK4/CyclinD1, CDK6/CyclinD2, AMPK, and c-Src.
Molecular Formula
C24H29N7O2.HCl
Targets
CDK4/CyclinD1: 11 nM; CDK6/CyclinD2: 15 nM; AMPK: >10 μM; c-Src: >10 μM
Solubility
Warmed DMSO: 3 mg/mL (6.19 mM); Water: 30 mg/mL (61.98 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
PD0332991 HCl is used to explore its selective inhibition of CDK4/6 and its implications for treating cancers driven by CDK4/6 activity.
