CDK inhibitor PF 477736, Purity ≥98%

Synonym: 952021-60-2; PF-0044736; PF0044736; CDK inhibitor

CAS Number: 952021-60-2
Compound CID: 135565545

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF 477736, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets Chk1, Chk2, Fms, and VEGFR2.

Molecular Weight

419.48

Molecular Formula

C₂₂H₂₅N₇O₂

Targets

Chk1: 0.49 nM (Ki); Chk2: 47 nM (Ki); Fms: 10 nM (Ki); VEGFR2: 8 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 5 mg/mL (11.92 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF 477736 can be used to study the inhibition of CHK1 in cancer cells and its role in regulating cell cycle checkpoints.