CDK inhibitor PHA-848125, Purity ≥98%

Synonym: 802539-81-7; Milciclib; PHA848125; CDK inhibitor

CAS Number: 802539-81-7
Compound CID: 16718576

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PHA-848125, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK7/CyclinH, TrkA, CDK1/CyclinB, and CDK2/CyclinA.

Molecular Weight

460.6

Molecular Formula

C₂₅H₃₂N₈O

Targets

CDK7/CyclinH: 150 nM; TrkA: 53 nM; CDK1/CyclinB: 398 nM; CDK2/CyclinA: 45 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 91 mg/mL (197.58 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PHA-848125 can be used to study its dual inhibition of CDKs and TRKA/B/C, and its potential therapeutic effects in cancer.

Storage

Store at -20ºC.