Properties
Description
Purvalanol A, soluble in warmed DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets Cdc2/CyclinB, CDK2/CyclinA, CDK2/CyclinE, CDK4/CyclinD1.
Molecular Formula
C19H25ClN6O
Targets
Cdc2/CyclinB: 4 nM; CDK2/CyclinA: 70 nM; CDK2/CyclinE: 35 nM; CDK4/CyclinD1: 850 nM
Solubility
Warmed DMSO: 53 mg/mL (136.28 mM); Water: Insoluble; Warmed ethanol: 11 mg/mL (28.28 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Purvalanol A can be employed to investigate the inhibition of CDKs and its impact on cell cycle regulation.
