CDK inhibitor Purvalanol A, Purity ≥98%

Synonym: 212844-53-6; NG-60; CDK inhibitor

CAS Number: 212844-53-6
Compound CID: 456214

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Purvalanol A, soluble in warmed DMSO and warmed ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets Cdc2/CyclinB, CDK2/CyclinA, CDK2/CyclinE, CDK4/CyclinD1.

Molecular Weight

388.89

Molecular Formula

C₁₉H₂₅ClN₆O

Targets

Cdc2/CyclinB: 4 nM; CDK2/CyclinA: 70 nM; CDK2/CyclinE: 35 nM; CDK4/CyclinD1: 850 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 53 mg/mL (136.28 mM); Water: Insoluble; Warmed ethanol: 11 mg/mL (28.28 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Purvalanol A can be employed to investigate the inhibition of CDKs and its impact on cell cycle regulation.