CDK inhibitor R547, Purity ≥98%

Synonym: 741713-40-6; R-547; CDK inhibitor

CAS Number: 741713-40-6
Compound CID: 6918852

Product Size

5 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

R547, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1/CyclinB, CDK2/CyclinE, AuroraA, and CDK4/CyclinD1.

Molecular Weight

441.45

Molecular Formula

C₁₈H₂₁F₂N₅O₄S

Targets

CDK1/CyclinB: 2 nM (Ki); CDK2/CyclinE: 3 nM (Ki); AuroraA: >5 μM (Ki); CDK4/CyclinD1: 1 nM (Ki)

Form

Lyophilized powder

Purity

Solubility

DMSO: 56 mg/mL (126.85 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

R547 can be employed to study its inhibition of CDKs and its anticancer effects in preclinical models.