Properties
Description
Ro 3306, soluble in warmed DMSO and insoluble in water and ethanol, is an CDK kinase inhibitor that disrupts cell division processes. It targets PKCδ, SGK, Akt, and CDK1.
Molecular Formula
C18H13N3OS2
Targets
PKCδ: 318 nM (Ki); SGK: 497 nM (Ki); Akt: >2000 nM (Ki); CDK1: 20 nM (Ki)
Solubility
Warmed DMSO: 12 mg/mL (34.14 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Ro 3306 can be used to explore the inhibition of CDK1 and its implications for cell cycle arrest.
