Properties
Description
Senexin A, soluble in DMSO and ethanol and insoluble in water, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK19 and CDK8.
Molecular Formula
C17H14N4
Targets
CDK19: 0.31 μM (Kd); CDK8: 0.83 μM (Kd)
Solubility
DMSO: 46 mg/mL (167.69 mM; Water: Insoluble; Ethanol: 46 mg/mL (167.69 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Senexin A can be used to study the inhibition of CDK8 and CDK19-mediated signaling pathways.