Properties
Description
THZ2, soluble in DMSO, water and ethanol, is an CDK kinase inhibitor that disrupts cell division processes. It targets CDK1, CDK2, CDK5, and CDK7.
Molecular Formula
C31H28ClN7O2
Targets
CDK1: 96.9 nM; CDK2: 222 nM; CDK5: 134 nM; CDK7: 13.9 nM
Solubility
DMSO: 93 mg/mL (164.29 mM); Water: <1 mg/mL; Ethanol: <1 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
THZ2 is utilized to study covalent inhibition of CDK7 and its impact on transcription and cancer cell proliferation.
