Cellulose Sodium Phosphate Analysis Service

Your Trusted Partner in Cellulose Sodium Phosphate (CSP) Analysis

CSP, also known as sodium carboxymethyl cellulose and CM-cellulose is a water-soluble substance derived from cellulose and often used for its ability to inhibit hypercalcemia and hypercalciuria. CSP is prepared by phosphorylation of alpha-cellulose. CD BioGlyco provides comprehensive Pharmaceutical and Biological Analysis Services to ensure the effectiveness of drugs and biological. In particular, we have deep expertise and experience in the field of CSP analysis, allowing us to deeply analyze the important properties of this key material.

Fig.1 CSP analysis service. (CD BioGlyco)

Chemical detection/characterization:
- Elemental analysis: We determine the content of carbon, hydrogen, nitrogen, phosphorus, and other elements in CSP to understand its chemical composition through elemental analysis.
- Mass spectrometry (MS): We use MS techniques to isolate and analyze the individual chemical components.
- Nuclear magnetic resonance (NMR): NMR spectroscopy is a technique often used in the study of the physical, chemical, and biochemical properties of substances like CSP. We use NMR to capture images at an exact molecular level, thus providing details about molecules' structure, sequence, and quantity.
- Infrared spectroscopy (IR): IR is used to identify the chemical bonds within a substance, thus enabling the identification and quantification of CSP.
- High-performance liquid chromatography (HPLC): We use HPLC to separate identify, and quantify each component in a mixture.
Biological detection/characterization:
- Biochemical analysis: To detect and analyze CSP in biological systems, various techniques including enzymatic assays and phosphate analysis assays quantify sodium phosphate.
- Microscopy analysis: We use microscopy techniques to study physical interactions between CSP and biological matter.
- Protein binding assay: To understand how CSP may interact with biological proteins, various techniques including affinity chromatography, bio-layer interferometry, and surface plasmon resonance monitor the affinity of CSP for a given biomolecule in real time.
- Cytotoxicity assay: We culture CSP with different types of cells to observe the growth, reproduction, and morphological changes of the cells, and evaluate its toxicity and compatibility with cells.
- Hemocompatibility assay: For applications involving blood contact, we use this assay to evaluate the reaction of CSP when in contact with blood, such as coagulation, platelet adhesion, etc.
Additionally, we offer cellulose sodium phosphate for oral suspension analysis including calcium binding capacity assay, free phosphate assay, inorganic bound phosphate assay, etc.

Publication Data

Technology: Elemental analysis, Solid-state ¹³C and ³¹P NMR, Conductimetric titration analysis

Journal: Carbohydrate polymers

IF: 11.2

Published: 2020

Results: The authors utilized various phosphate salts with differing solubility constants (Ks) to enhance modification efficiency. They examined the phosphorylated cellulose pulps via elemental analysis, solid-state ¹³C and ³¹p NMR, and conductimetric titration method. There was no discernible effect from Ks, but a significant counterion effect was detected. The authors also scrutinized the impact of various factors such as pH, cellulose concentration, temperature, and urea content on phosphorylation efficiency. To conclude, they assessed the chemical functionalization and phosphorus penetration into the cellulose fibers using X-ray photoelectron spectroscopy (XPS), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), time-of-flight secondary ion mass spectrometry (ToF-SIMS), and solid-state NMR.

Here are some of the results shown in this article:

Fig.2 Evaluation of phosphorus position on the cellulose fibers. (Rol, et al., 2020)

Frequently Asked Questions

What are the functional properties of CSP?

CSP has anti-urinary stone activity and anticoagulant effects. It also has good biocompatibility and degradability.

What indicators does the CSP analysis service mainly detect?

The indicators tested by our CSP analysis service include but are not limited to its purity, chemical structure, molecular weight distribution, solubility, stability, and biocompatibility. By accurately measuring these indicators, we comprehensively evaluate the quality and performance of CSP and provide clients with accurate and reliable data support.

CD Bioglyco provides a full range of Pharmaceutical Analysis Services, including quality control, ingredient analysis, and efficacy evaluation. Importantly, our CSP analysis service provides a comprehensive analysis of CSPs and their performance across a variety of applications. In addition, we offer a variety of tests for cellulose sodium phosphate for oral suspensions, including the determination of calcium-binding capacity, free phosphate, and inorganically bound phosphate. Please feel free to contact us if you have any questions or needs about our CSP analysis services.

Reference

Rol, F.; et al. Cellulose phosphorylation comparison and analysis of phosphorate position on cellulose fibers. Carbohydrate polymers. 2020, 229: 115294.

This service is for Research Use Only, not intended for any clinical use.