Properties
Description
VX-661, soluble in DMSO and insoluble in ethanol and water, blocks the activity of the cystic fibrosis transmembrane conductance regulator protein, which plays a crucial role in the movement of chloride ions across cell membranes. It targets F508del-CFTR.
Molecular Formula
C26H27F3N2O6
Solubility
DMSO: 95 mg/mL (182.51 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
VX-661 is a CFTR modulator investigated for its potential to improve chloride transport in diseases like cystic fibrosis.
