Chloride channel inhibitor VX-770, Purity ≥98%

Synonym: 873054-44-5; Chloride channel inhibitor; Kalydeco; VX770

MDL: MFCD17171361
CAS Number: 873054-44-5
Compound CID: 16220172

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

VX-770, soluble in DMSO and insoluble in ethanol and water, blocks the activity of chloride channels, which play a vital role in maintaining cellular ion balance. It targets F508del-CFTR (Fisher rat thyroid cells) and G551D-CFTR (fisher rat thyroid cells).

Molecular Weight

392.5

Molecular Formula

C₂₄H₂₈N₂O₃

Targets

F508del-CFTR (Fisher rat thyroid cells): 25 nM (EC₅₀); G551D-CFTR: 100 nM (EC₅₀)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 69 mg/mL (175.8 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

VX-770 (Ivacaftor) is used as a chloride channel inhibitor in research focusing on cystic fibrosis to enhance CFTR (cystic fibrosis transmembrane conductance regulator) function.