CRM1 inhibitor, KPT 335, Purity ≥98%

Synonym: 1392136-43-4; Verdinexor; 2-[(5-Chloro-2-{[4-(1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]-N-methylbenzamide; (Z)-3-(3-(3,5-Bis-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylohydrazide; (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide; CRM1 inhibitor

CAS Number: 1392136-43-4
Compound CID: 71492799

Product Size

5 mg; 10 mg; 20 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

KPT 335, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of membrane transporters-ion channels by inhibiting CRM1. The molecular weight of the compound is 442.32, and its molecular formula is C₁₈H₁₂F₆N₆O.

Molecular Weight

442.32

Molecular Formula

C₁₈H₁₂F₆N₆O

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 83 mg/mL (187.65 mM); Water: insoluble; Ethanol (warmed): 10 mg/mL; In vivo: 5% DMSO + corn oil, 14 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

KPT 335 plays a key role in promoting the accumulation of tumor suppressor proteins in the nucleus.