CRM1 inhibitor, KPT276, Purity ≥98%

Synonym: 1421919-75-6; KPT-276; KPT 276; (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one; CRM1 inhibitor

MDL: MFCD27937049
CAS Number: 1421919-75-6
Compound CID: 71496742

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

KPT276, soluble in DMSO and insoluble in water and ethanol, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of membrane transporters-ion channels by inhibiting CRM1. The molecular weight of the compound is 426.26, and its molecular formula is C₁₆H₁₀F₈N₄O.

Molecular Weight

426.26

Molecular Formula

C₁₆H₁₀F₈N₄O

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 17 mg/mL (39.87 mM); Water: insoluble; Ethanol: insoluble; In vivo: 30% PEG400 + 0.5% Tween80 + 5% propylene glycol, 4 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

KPT276 can be used for its potential in various malignancies, aiming to improve outcomes in cancers with aberrant nuclear transport.