Properties
Description
Selinexor, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of membrane transporters-ion channels by inhibiting CRM1. The molecular weight of the compound is 443.31, and its molecular formula is C17H11F6N7O.
Molecular Formula
C17H11F6N7O
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 78 mg/mL (175.94 mM); Water: insoluble; Ethanol: 36 mg/mL (81.21 mM); In vivo: 2% DMSO + 40% PEG 300 + 5% Tween80 + ddH2O, 3 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
Selinexor displays the significant potential to act as an effective inhibitor of nuclear export (SINE) that blocks the export of tumor suppressor proteins from the nucleus, enhancing their activity.
