Glycolipids play an important role in the biological process. CD BioGlyco can customize and synthesize different types and different modified glycolipids. We have confidence to be your essential research assistant in the field of glycobiology.

Background

Glycolipids refer to lipid compounds containing sugar-based ligands. It is a type of amphiphilic molecule that exists widely in organisms. Glycolipids are an important and complex class of glycoconjugates. According to the structure of the lipid moiety (which may be diacylglycerol, polyisoprene, sterol or ceramide), glycolipids are divided into three main categories, namely glyceroglycolipids, glycosylphosphatidylinositol and glycosphingolipids, characterized by the diversity of structure and function. The main roles of glycolipids are to maintain membrane stability, promote cell-cell recognition and interaction, and affect immune response.

The general properties of glycolipids include surfactant properties, gelling properties, antimicrobial and antitumor properties. Glycolipids have great potential in the pharmaceutical and biomedical fields. Possible applications include the use of natural glycolipids or their analogs as anti-infectives or vaccine adjuvants, or to encapsulate certain drugs. Current areas of scientific interest include the synthesis of various types of glycolipids, the biological evaluation of glycolipids, the determination of structure-activity relationships, and the structural analysis of natural glycolipids.

Fig 1. Glycolipids with sterol, ceramide or diacylglycerol as hydrophobic backbone (Cortés-Sánchez, A. J.; et al. 2013)

Services

The glycolipid synthesis service in CD BioGlyco includes but is not limited to the following technologies.

• Our glycolipid synthesis method is more time-saving and efficient than traditional methods, challenging the synthesis of difficult compounds. We can obtain highly pure and homogeneous samples through advanced purification and detection technology.
• We can synthesize glycolipids with fluorescent labeling on the functional groups of lipids and/or other compounds. In addition, other modifications can be provided upon request, including extension and truncation of lipid chains, introduction of other compounds to replace lipids, and glycosyl sulfation, etc.

Applications

• Cell recognition and interaction research
• Drug delivery system development
• Function and structure research of glycolipids
• Pharmaceutical and biomedical research

Advantages of Us

• Fully optimized synthesis routes
• Various modifications can be made to glycolipids according to requirements
• Validation step after synthesis to ensure quality
• Experienced and well-trained researchers

CD BioGlyco provides customers with optimized glycolipids synthesis services to ensure time-saving and high efficiency. All our synthetic products will undergo multiple inspection processes to ensure that the products provided to customers are of high purity and high quality.

Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.

References:

1. Manna, M.; et al. The challenges of understanding glycolipid functions: An open outlook based on molecular simulations. Biochim. Biophys. Acta. 2013, 12.
2. Cortés-Sánchez, A. J.; et al. Biological activity of glycolipids produced by microorganisms: New trends and possible therapeutic alternatives. Microbiological Research. 2013, 168: 22-32.