CD BioGlyco provides a variety of different glycopeptides synthesis solutions, and can customize synthesis program according to customers' research needs. We have confidence to be your essential research assistant in the field of glycobiology.  

Background

Carbohydrates (glycans) are attached to amino acid side chains to produce glycoproteins. Glycoproteins play an important role in biological processes, such as cell adhesion, differentiation and proliferation, as well as many pathological processes of viral and bacterial infections and cancer metastasis. As a result, research interest in glycoproteins has been growing. Research in this field can help us understand glycobiology at the molecular level and provide novel ideas for the early diagnosis and treatment of human diseases.

The biosynthesis of oligosaccharides involves a series of enzymatic reactions that are not controlled by templates or transcription, so the process is easily affected by enzyme activity and substrate availability. Therefore, the glycans of each glycoprotein may have many different glycoforms. They are difficult to separate, almost impossible to obtain a homogeneous glycoform of glycoprotein from nature.

In recent years, new and effective methods for synthesizing these compounds have been developed, which allows researchers to explore glycopeptides at a deeper level. As a result, many vaccines are expected to be developed for HIV, cancer, or many other clinical diseases and novel antibiotics to overcome drug resistance.

Fig 1. Examples of N- and O-linked glycans found in mammalian glycopeptides. (Guo, Z.; Shao, N. 2005)

Services

CD BioGlyco provides three strategies for glycopeptides synthesis using free glycans as key intermediates, or customized synthesis schemes based on customer's research needs.

• The first strategy is based on the chemoselective ligation of the completed oligosaccharide to the full-length peptide. This scheme does not require protections of glycans. An obvious advantage of this strategy is its convergence. But this is basically limited to the synthesis of N-linked glycopeptides.
• The second synthesis strategy follows the traditional peptide synthesis method, in which amino acids and unprotected glycolyl amino acids are sequential installed in order to synthesize glycopeptides. This strategy has achieved the synthesis of O- and N- linked glycopeptides on the basis of solution phase, solid phase and enzymatic peptide extension.
• The third synthesis strategy involves the sequential extension of glycans. Preparing free monosaccharides according to the second strategy, thereafter, the glycan is extended by enzymatic reactions.

Applications

• Function and structure research of glycopeptides
• Research on the molecular level of glycobiology
• Pharmacological and biomedical applications of glycopeptides
• Vaccine and new antibiotic development

Advantages of Us

• The synthetic route can be customized according to needs
• Sophisticated instruments and first-class synthesis technology
• Able to synthesize complex glycopeptides
• One-stop service

CD BioGlyco has quite a wealth of experience in glycopeptide synthesis. Our efficient work and thoughtful service attitude have won us a lot of praise internationally.

Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.

References:

1. Guo, Z.; Shao, N. Glycopeptide and glycoprotein synthesis involving unprotected carbohydrate building blocks. Medicinal Research Reviews. 2005, 25(6): 655-678.
2. Ashford, P.A.; Bew, S.P. Recent advances in the synthesis of new glycopeptide antibiotics. Chem. Soc. Rev. 2012, 41: 957-978.