CD BioGlyco has advanced chemical and enzyme methods and powerful analytical tools to provide customers with high-quality services to synthesize monosaccharides and their derivatives. We expect to share our extensive expertise and cutting-edge technology in the field of glycobiology.

Background

Monosaccharides are the simplest carbohydrates and cannot be hydrolyzed to smaller carbohydrates. In general, monosaccharides can be classified according to different characteristics, such as the position of the carbonyl group and the number of carbon atoms in monosaccharides. In the last few years, due to the continuing discovery of bioactive compounds containing monosaccharide units as their structural components and increasing application of monosaccharide as chiral starting materials in synthesis, the interest of researchers in monosaccharide synthesis has considerably increased.

The isolation of Monosaccharides from natural sources is difficult. Multistep chemical or enzymatic synthesis is an effective way to synthesize monosaccharides and their derivatives. Synthesis reactions of monosaccharides include Wittig reactions, oxirane ring openings, Diels-Alder types, and organometallic reagents. Several remarkable synthetic achievements have been made in the field of monosaccharide synthesis in the past few years. Natural products can be assembled by monosaccharide and carbocyclic ring systems through different schemes for the radical cyclization strategies. The obtained target molecules were used for cycloadditions reactions to monosaccharide derivatives to construct the carbocyclic ring systems in chiral natural products.

Fig.1 Examples of synthesis of monosaccharide building blocks. (Mohanmukherjee, 2019)

Synthesis Services

CD BioGlyco is proficient in multi-step chemical or enzymatic synthesis techniques for the custom synthesis of monosaccharides and their derivatives. The services we can provide include but are not limited to:

• Synthesis of monosaccharides with chemical modifications, including distinct fluorescence labeling, reducing terminal or individual functional group in monosaccharides by acylation, biotinylation, and so on.
• Synthesis of monosaccharide labeled with stable isotope containing ¹³C, ²H, ¹⁵N, or ¹⁸O.
• Synthesis of various monosaccharides and their derivatives.

Applications

• Functional polysaccharides and glycoconjugates synthesis
• Enzyme inhibitors research
• Various activity tests

Advantages of Us

• Outstanding scientists specialize in glycan synthesis
• Optimized synthesis service of monosaccharides and their derivatives
• Multiple inspection processes of synthetic products to ensure quality.
• Fast, reliable, customized, and meet customer expectations

As a provider for carbohydrate synthesis, CD BioGlyco has a first-class experimental platform and experienced researchers to provide customers with optimized monosaccharide synthesis services. In addition, we will perform a verification step after synthesis to ensure high quality and high purity. If you are interested in our services, please contact us for more detailed information.

Reference:

1. Mohanmukherjee, M.; et al. Towards the complete synthetic O-antigen of vibrio cholerae O1, serotype inaba: improved synthesis of the conjugation-ready upstream terminal hexasaccharide determinant. RSC Advances. 2019, 9(62):36440-36454.